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multiomics_analysis_for_dementia [2018/11/16 20:53]
admin [Subprojects]
multiomics_analysis_for_dementia [2019/06/07 17:55] (current)
admin [Related work]
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   - The Cohorts for Heart and Aging Research in Genomic Epidemiology ([[http://​www.chargeconsortium.com|CHARGE]]) Consortium.   - The Cohorts for Heart and Aging Research in Genomic Epidemiology ([[http://​www.chargeconsortium.com|CHARGE]]) Consortium.
-  - The Trans-Omics for Precision Medicine ([[https://​www.nhlbiwgs.org|TOPMed]]) program. The TOPMed Omics [[http://​oncinfo.org/​_media/​wiki:​topmed_omics_survey.pdf|Survey]] in 2017 includes Framingham Heart Study (FHS) details, which are described clearer in [[http://​oncinfo.org/​_media/​wiki:​omics_fhs.pdf|2016]].+  - The Trans-Omics for Precision Medicine ([[https://​www.nhlbiwgs.org|TOPMed]]) program. The TOPMed Omics [[http://​oncinfo.org/​_media/​wiki:​topmed_omics_survey.pdf|Survey]] in 2017 includes Framingham Heart Study (FHS) details, which are described clearer in [[http://​oncinfo.org/​_media/​wiki:​omics_fhs.pdf|2016]]. [[https://​www.ncbi.nlm.nih.gov/​projects/​gap/​cgi-bin/​molecular.cgi?​study_id=phs000363.v17.p11&​phv=173423&​phd=4119&​pha=&​pht=2941&​phvf=&​phdf=&​phaf=&​phtf=&​dssp=1&​consent=&​temp=1|SABRe]] is a substudy of FHS and has mRNA and miRNA data.
   - Exome Sequencing Project ([[http://​evs.gs.washington.edu|ESP]]),​ richly-phenotyped for heart, lung and blood disorders.   - Exome Sequencing Project ([[http://​evs.gs.washington.edu|ESP]]),​ richly-phenotyped for heart, lung and blood disorders.
   - Alzheimer'​s Disease Sequencing Project ([[https://​www.niagads.org/​adsp/​content/​study-design|ADSP]]),​ WES and WGS of thousands of AD and control samples.   - Alzheimer'​s Disease Sequencing Project ([[https://​www.niagads.org/​adsp/​content/​study-design|ADSP]]),​ WES and WGS of thousands of AD and control samples.
-  - Allen Brain [[http://​portal.brain-map.org/​|Atlases]] has many different data types, but from a few mouse and human samples. RNA-Seq data of hundreds of dementia cases.+  - Allen Brain [[http://​portal.brain-map.org/​|Atlases]] has many different ​[[http://​aging.brain-map.org/​overview/​home|downloadable]] ​data types, but from a few mouse and human samples. RNA-Seq data of hundreds of dementia cases.
   - The Alzheimer'​s Disease Neuroimaging Initiative ([[http://​adni.loni.usc.edu/​data-samples/​data-types/​|ADNI]]) has genetic and imaging data of 1-3 K samples.   - The Alzheimer'​s Disease Neuroimaging Initiative ([[http://​adni.loni.usc.edu/​data-samples/​data-types/​|ADNI]]) has genetic and imaging data of 1-3 K samples.
   - The Image and Data Archive ([[https://​ida.loni.usc.edu|IDA]]) contains mostly image data on 43,290 subjects from 119 studies.   - The Image and Data Archive ([[https://​ida.loni.usc.edu|IDA]]) contains mostly image data on 43,290 subjects from 119 studies.
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 ===== Related work ===== ===== Related work =====
  
-1- An interactive timeline of Alzheimer'​s disease by [[https://​www.alzforum.org/​timeline/​alzheimers-disease#​2010|AlzForum]].+  ​- An interactive timeline of Alzheimer'​s disease by [[https://​www.alzforum.org/​timeline/​alzheimers-disease#​2010|AlzForum]]
 +  - Mathys, Hansruedi, et al. "​Single-cell transcriptomic analysis of Alzheimer’s disease."​ Nature ([[https://​www.nature.com/​articles/​s41586-019-1195-2|2019]]). \\  Radek'​s summary: "​Showing single cell transcriptomic analysis on brain tissues from ~50 patients with Alzheimer'​s disease. Subpopulations of glia and neurons expressed different gene signatures associated with AD. These enormous cataloging data may help to further pinpoint pathways associated with AD.", and his {{:​wiki:​img_20190516_162440263.jpg?​linkonly|plan}}.