Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
Next revisionBoth sides next revision
hepatocellular_carcinoma [2019/09/10 19:56] – [Current clinical risk assessment] adminhepatocellular_carcinoma [2019/09/11 17:02] – [Publication:] admin
Line 44: Line 44:
  
 ==== Publication: ==== ==== Publication: ====
-Jessica Zavadil, Maryanne Herzig, Kim Hildreth, Amir Foroushani, William Boswell, Ronald Walter, Robert Reddick, Hugh White, Habil Zare. C3HeB/FeJ Mice Mimic Gene Expression and Pathobiological Features of Human Hepatocellular Carcinoma,  //Molecular Carcinogenesis//, In press. + 
-{{:wiki:public:jessica_compare.png?direct&400|}}+Jessica Zavadil, Maryanne Herzig, Kim Hildreth, Amir Foroushani, William Boswell, Ronald Walter, Robert Reddick, Hugh White, Habil Zare. "C3HeB/FeJ Mice mimic many aspects of gene expression and pathobiological features of human hepatocellular carcinoma." [[https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22929|Molecular carcinogenesis ]]58.3 (2019): 309-320. 
 + 
 +{{:wiki:public:jessica_compare.png?direct&400}} 
 + 
 ==== Project 2: ==== ==== Project 2: ====
  
Line 60: Line 64:
   - Ching, Travers, Sijia Huang, and Lana X. Garmire. "Power analysis and sample size estimation for RNA-Seq differential expression." //[[http://rnajournal.cshlp.org/content/early/2014/09/22/rna.046011.114|rna]]//20.11 (2014): 1684-1696.   - Ching, Travers, Sijia Huang, and Lana X. Garmire. "Power analysis and sample size estimation for RNA-Seq differential expression." //[[http://rnajournal.cshlp.org/content/early/2014/09/22/rna.046011.114|rna]]//20.11 (2014): 1684-1696.
   - Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma, [[http://www.cell.com/cell/abstract/S0092-8674(17)30639-6?innerTabgraphical_S0092867417306396|Cell]], 2017 [{{:ally-copmprehensive_and_integrative_genomic_char_of_hcc-cell-2017.pdf|pdf}} ]. TCGA's HCC data and subtyping using DNA copy number, DNA methylation, mRNA expression, miRNA expression and RPPA (protein expression). Links to the MDACC dataset with 100 HCC samples.   - Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma, [[http://www.cell.com/cell/abstract/S0092-8674(17)30639-6?innerTabgraphical_S0092867417306396|Cell]], 2017 [{{:ally-copmprehensive_and_integrative_genomic_char_of_hcc-cell-2017.pdf|pdf}} ]. TCGA's HCC data and subtyping using DNA copy number, DNA methylation, mRNA expression, miRNA expression and RPPA (protein expression). Links to the MDACC dataset with 100 HCC samples.
- 
----- 
- 
-===== Current clinical risk assessment ===== 
- 
-Percent rise in AFP and the total amount of AFP (alpha feto protein) is a common risk indicator for HCC. If it rises quickly it suggests aggressive tumor. If AFP is over 500 it suggests vascular involvement or aggressiveness. If regionally ablated and recurs within three months, this is also suggestive of an aggressive tumor. Other criteria include: disease burden, CP cirrhosis, portal vein thrombosis, AFP. CLIP score and BCLC score are also used in clinic. 
  
 ---- ----