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| how_to [2019/10/11 12:50] – [Use git via proxy or vpn?] admin | how_to [2019/10/11 12:53] – [Use git via proxy or vpn?] admin |
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| **Avoid misinterpretation of biological experiments?** \\ | **Avoid misinterpretation of biological experiments?** \\ |
| [[https://www.nature.com/nrc/journal/v17/n7/full/nrc.2017.32.html|Reasoning]] must be logical. Report enough details of the methods to reproduce the results. Assess the robustness of the findings with respect to minor perturbations to the experimental settings. To prove that drug A targets protein X, it is not sufficient to confirm that treatment with A leads to killing cells that have X. Maybe the cells are killed because of some other mechanism. Use "rescue experiments" as in the A=imatinib X=BCR–ABL case. | [[https://www.nature.com/nrc/journal/v17/n7/full/nrc.2017.32.html|Reasoning]] must be logical. Report enough details of the methods to reproduce the results. Assess the robustness of the findings with respect to minor perturbations to the experimental settings. To prove that drug A targets protein X, it is not sufficient to confirm that treatment with A leads to killing cells that have X. Maybe the cells are killed because of some other mechanism. Use "rescue experiments" as in the A=imatinib X=BCR–ABL case. Always, avoid [[https://elifesciences.org/articles/48175|these]] ten common statistical mistakes. |
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