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multiomics_analysis_for_dementia [2018/11/01 18:39] – [Data] adminmultiomics_analysis_for_dementia [2018/11/01 19:19] – [Data] admin
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   - The Image and Data Archive ([[https://ida.loni.usc.edu|IDA]]) contains mostly image data on 43,290 subjects from 119 studies.   - The Image and Data Archive ([[https://ida.loni.usc.edu|IDA]]) contains mostly image data on 43,290 subjects from 119 studies.
   - Several studies share their data through Accelerating Medicines Partnership - Alzheimer's Disease ([[https://www.synapse.org/#!Synapse:syn5550382|AMP-AD]]) including:   - Several studies share their data through Accelerating Medicines Partnership - Alzheimer's Disease ([[https://www.synapse.org/#!Synapse:syn5550382|AMP-AD]]) including:
-      - The Adult Changes in Thought ([[https://www.synapse.org/#!Synapse:syn5759376|ACT]]) measured ~4K __proteins__  in ~50 brains and performed WGCNA. Also, proteome data in BLSA (~100 brains), Banner (~200). +      - The Adult Changes in Thought ([[https://www.synapse.org/#!Synapse:syn5759376|ACT]]) measured ~4K __proteins__  in ~50 brains and performed WGCNA. Also, proteome data in BLSA (~100 brains), Banner (~200), and UPPpilot (~200). 
-      - CHDWB and HBTRC, each has a __gene expression__  profile from ~500 brains, MC-CAA (75), MCADGS (~100 RNA-Seq and GWAS samples), . +      - CHDWB and HBTRC, each has a __gene expression__  profile from ~500 brains, MC-CAA (75), MCADGS (~100 RNA-Seq and GWAS samples). 
-  -+      - The Mount Sinai Brain Bank ([[https://www.synapse.org/#!Synapse:syn3159438|MSBB]]) includes proteome and gene expression profiles from hundreds of samples. 
 +      - The [[https://www.synapse.org/#!Synapse:syn5550404|MayoRNAseq]] includes WGS and RNA-Seq data from 275 Cerebellum (CBE) and 276 Temporal cortex (TCX) samples. 
 +  - The Religious Orders Study and Memory and Aging Project ([[https://www.synapse.org/#!Synapse:syn3219045|ROSMAP]]) is the **richest**  dataset in AMP-AD in terms of variety of data types, which include gene expression, genome, proteome, metabolome, and image data. Also, DNA methylation, miRNA, WGS, WES, and even H3K9Ac are available for ~1K samples.The dataset is very well [[https://www.radc.rush.edu/docs/omics.htm|documented]].