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multiomics_analysis_for_dementia [2018/11/01 19:19] – [Data] adminmultiomics_analysis_for_dementia [2018/11/01 19:22] – [Objectives] admin
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 ===== Objectives ===== ===== Objectives =====
-Determine biomarkers for Alzheimer's and other neurodegenerative diseases using comprehensive analysis of various data including genomics, epigenomics, metabolomics, proteomics, etc.+ 
 +Determine biomarkers for Alzheimer's and other neurodegenerative diseases using comprehensive analysis of multi-omics data including genomics, epigenomics, metabolomics, proteomics, etc.
  
  
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       - The Mount Sinai Brain Bank ([[https://www.synapse.org/#!Synapse:syn3159438|MSBB]]) includes proteome and gene expression profiles from hundreds of samples.       - The Mount Sinai Brain Bank ([[https://www.synapse.org/#!Synapse:syn3159438|MSBB]]) includes proteome and gene expression profiles from hundreds of samples.
       - The [[https://www.synapse.org/#!Synapse:syn5550404|MayoRNAseq]] includes WGS and RNA-Seq data from 275 Cerebellum (CBE) and 276 Temporal cortex (TCX) samples.       - The [[https://www.synapse.org/#!Synapse:syn5550404|MayoRNAseq]] includes WGS and RNA-Seq data from 275 Cerebellum (CBE) and 276 Temporal cortex (TCX) samples.
-  - The Religious Orders Study and Memory and Aging Project ([[https://www.synapse.org/#!Synapse:syn3219045|ROSMAP]]) is the **richest**  dataset in AMP-AD in terms of variety of data types, which include gene expression, genome, proteome, metabolome, and image data. Also, DNA methylation, miRNA, WGS, WES, and even H3K9Ac are available for ~1K samples.The dataset is very well [[https://www.radc.rush.edu/docs/omics.htm|documented]].+  - The Religious Orders Study and Memory and Aging Project ([[https://www.synapse.org/#!Synapse:syn3219045|ROSMAP]]) is the **richest**  dataset in AMP-AD in terms of variety of data types, which include gene expression, genome, proteome, metabolome, and image data. Also, DNA methylation, miRNA, WGS, WES, and even H3K9Ac are available for ~1K samples. The dataset is very well [[https://www.radc.rush.edu/docs/omics.htm|documented]].