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multiomics_analysis_for_dementia [2019/08/01 00:41] – [Subprojects] admin | multiomics_analysis_for_dementia [2019/11/07 15:24] – [Data] admin |
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- Mathys, Hansruedi, et al. "**Single-cell** transcriptomic analysis of Alzheimer’s disease." Nature ([[https://www.nature.com/articles/s41586-019-1195-2|2019]]). \\ Radek's summary: "Showing ~80K single cell transcriptomic analysis on brain tissues from ~50 patients with Alzheimer's disease. Subpopulations of glia and neurons expressed different gene signatures associated with AD. These enormous cataloging data may help to further pinpoint pathways associated with AD.", and his [[:plan|]]. Habil's [[https://docs.google.com/presentation/d/1u2rv9FExW44JfJsqPjenJcCsCFnOSUbJUxQwalviNHk/edit#slide=id.p|presentation]] in Biggs journal club on 2 July 2019. | - Mathys, Hansruedi, et al. "**Single-cell** transcriptomic analysis of Alzheimer’s disease." Nature ([[https://www.nature.com/articles/s41586-019-1195-2|2019]]). \\ Radek's summary: "Showing ~80K single cell transcriptomic analysis on brain tissues from ~50 patients with Alzheimer's disease. Subpopulations of glia and neurons expressed different gene signatures associated with AD. These enormous cataloging data may help to further pinpoint pathways associated with AD.", and his [[:plan|]]. Habil's [[https://docs.google.com/presentation/d/1u2rv9FExW44JfJsqPjenJcCsCFnOSUbJUxQwalviNHk/edit#slide=id.p|presentation]] in Biggs journal club on 2 July 2019. |
- The Brain eQTL Almanac ([[http://braineac.org/|Braineac]]) generated by UK Brain Expression Consortium (UKBEC) "comprises of genomic and transcriptome data of 134 brains from individuals free of neurodegenerative disorders. Up to 12 brain regions were extracted per brain in parallel for mRNA quantification." | - The Brain eQTL Almanac ([[http://braineac.org/|Braineac]]) generated by UK Brain Expression Consortium (UKBEC) "comprises of genomic and transcriptome data of 134 brains from individuals free of neurodegenerative disorders. Up to 12 brain regions were extracted per brain in parallel for mRNA quantification." |
| - Omics data were generated in [[https://www.neurodegenerationresearch.eu/it/cohort/the-rhineland-study/|Rhineland]] Study including DNA methylation from ~2K blood samples. Aslam Imtiaz presented these data in the NeuroCHARGE call on 2019-11-07. |
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