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multiomics_analysis_for_dementia [2024/06/28 01:37] – [Data] adminmultiomics_analysis_for_dementia [2024/07/24 19:53] (current) – [Data] admin
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   - [[https://bmbls.bmi.osumc.edu/scread/|scREAD]]: A Single-Cell RNA-Seq Database for Alzheimer’s Disease ([[https://www.cell.com/iscience/pdf/S2589-0042(20)30966-4.pdf|pdf]]). It covers 73 datasets from 15 studies, 10 brain regions, 713640 cells.Useful for: a) listing available datasets, b) easy preliminary DE analysis across cell types and disease vs. control conditions.   - [[https://bmbls.bmi.osumc.edu/scread/|scREAD]]: A Single-Cell RNA-Seq Database for Alzheimer’s Disease ([[https://www.cell.com/iscience/pdf/S2589-0042(20)30966-4.pdf|pdf]]). It covers 73 datasets from 15 studies, 10 brain regions, 713640 cells.Useful for: a) listing available datasets, b) easy preliminary DE analysis across cell types and disease vs. control conditions.
   - [[https://www.nature.com/articles/s41586-021-03910-8|Bhaduri]] 's 2021 snRNASeq of the developing human brain.   - [[https://www.nature.com/articles/s41586-021-03910-8|Bhaduri]] 's 2021 snRNASeq of the developing human brain.
-  - Leonenko, et al. (2021). Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. [[https://www.nature.com/articles/s41467-021-24082-z#Sec8|Nature communications]]. A comprehensive list of large dementia cohorts in the Methods. +  - Leonenko, et al. (2021). Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. [[https://www.nature.com/articles/s41467-021-24082-z#Sec8|Nature communications]]. A comprehensive list of large dementia cohorts in the Methods. 
 +  - Gabitto, Mariano I., et al. "Integrated multimodal cell atlas of Alzheimer’s disease." //bioRxiv//  (2023). Seattle Alzheimer’s Disease Brain Cell [[https://portal.brain-map.org/explore/seattle-alzheimers-disease|Atlas]], [[https://knowledge.brain-map.org/data/5IU4U8BP711TR6KZ843/2CD0HDC5PS6A58T0P6E/compare?cellType=Whole Taxonomy&geneOption=IL1B&metadata=Cognitive Status&comparison=dotplot|browsable]] from knowledge.brain-map.org. 
 +  - Sun, Na, et al. … Manolis Kellis. "Single-cell multi-region dissection of brain vasculature in Alzheimer’s Disease." //[[https://www.nature.com/articles/s41586-024-07606-7|Nature]]// (2024). snRNA-seq data of 1.3 million cells from 6 brain regions across 48 individuals with and without Alzheimer’s disease. 
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 ===== Collaborators ===== ===== Collaborators =====