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rapamycin [2019/07/29 17:28] – [Objectives] 89.187.177.110 | rapamycin [2019/07/29 18:35] – [DNA methylation analysis] admin |
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====== Rapamycin effects on aging-associated pathologies ====== | ====== Rapamycin effects on aging-associated pathologies ====== |
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====== Rapamycin effects on aging-associated pathologies ====== | |
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===== Objectives ===== | ===== Objectives ===== |
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- DNA methylation data of {{:wiki:public:plan_discussed_with_habil_07_24_19.docx|29 subjects}} were measured in 2019 using Infinium [[https://support.illumina.com/downloads/infinium-methylationepic-v1-0-product-files.html|MethylationEpic]] V1 Array. PBMC samples were collected before and after Rapamycin (16 subjects) and placebo (13 subjects) treatment for 6-8 weeks. | - DNA methylation data of {{:wiki:public:plan_discussed_with_habil_07_24_19.docx|29 subjects}} were measured in 2019 using Infinium [[https://support.illumina.com/downloads/infinium-methylationepic-v1-0-product-files.html|MethylationEpic]] V1 Array. PBMC samples were collected before and after Rapamycin (16 subjects) and placebo (13 subjects) treatment for 6-8 weeks. |
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===== Collaborators ===== | ===== Collaborators ===== |
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Dr. [[https://wp.uthscsa.edu/mimg/team-member/ellen-kraig-ph-d/|Ellen Kraig]], an immunologist from the University of Texas Health Science Center at San Antonio. | Dr. [[https://wp.uthscsa.edu/mimg/team-member/ellen-kraig-ph-d/|Ellen Kraig]], an immunologist, and Dr. [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/0V71EU5IM/Kellogg,-Dean-L.-Jr.|Dean Kellogg]], a physiologist, both from the University of Texas Health Science Center at San Antonio. |
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Dr. [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/0V71EU5IM/Kellogg,-Dean-L.-Jr.|Dean Kellogg]], a physiologist from the University of Texas Health Science Center at San Antonio. | |
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===== Data ===== | |
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- DNA methylation data of {{:wiki:public:plan_discussed_with_habil_07_24_19.docx|29 subjects}} were measured in 2019 using Infinium [[https://support.illumina.com/downloads/infinium-methylationepic-v1-0-product-files.html|MethylationEpic]] V1 Array. PBMC samples were collected before and after Rapamycin (16 subjects) and placebo (13 subjects) treatment for 6-8 weeks. | |
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===== Collaborators ===== | |
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Dr. [[https://wp.uthscsa.edu/mimg/team-member/ellen-kraig-ph-d/|Ellen Kraig]], an immunologist from the University of Texas Health Science Center at San Antonio. | |
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Dr. [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/0V71EU5IM/Kellogg,-Dean-L.-Jr.|Dean Kellogg]], a physiologist from the University of Texas Health Science Center at San Antonio. | ===== DNA methylation analysis ===== |
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| We follow the Bioconductor pipeline to identify the probes and regions that are differentially methylation due to Repamycin treatment. |
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