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rapamycin [2019/07/29 17:25] – [Related work] 89.187.177.110rapamycin [2019/07/29 18:46] (current) – [DNA methylation analysis] admin
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 ====== Rapamycin effects on aging-associated pathologies ====== ====== Rapamycin effects on aging-associated pathologies ======
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 ===== Objectives ===== ===== Objectives =====
  
-[[https://en.wikipedia.org/wiki/Sirolimus|Rapamycin]] is an inhibitor of the [[https://en.wikipedia.org/wiki/MTOR|mTOR]] pathway, which has been used in preventing rejection of solid organ allografts. In this multi-PI study on an older age healthy human cohort, we assess the usability and efficacy of Rapamycin in improving physical performance, cardiac and vascular health, and immune outcomes. This approach is motivated by the promising results that were observed in prior studies on mice models. Oncinfo contributes in this study through analysis of gene expression and DNA methylation profiles. +[[https://en.wikipedia.org/wiki/Sirolimus|Rapamycin]] is an inhibitor of the [[https://en.wikipedia.org/wiki/MTOR|mTOR]] pathway and it has been used in preventing rejection of solid organ allografts. In this multi-PI study on an older age healthy human cohort, we assess the usability and efficacy of Rapamycin in improving physical performance, cardiac and vascular health, and immune outcomes. This approach is motivated by the promising results that were observed in prior studies on mice models. Oncinfo contributes in this study through analysis of gene expression and DNA methylation profiles.
  
 ===== Data ===== ===== Data =====
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 ===== Collaborators ===== ===== Collaborators =====
  
-Dr. [[https://wp.uthscsa.edu/mimg/team-member/ellen-kraig-ph-d/|Ellen Kraig]], an immunologist from the University of Texas Health Science Center at San Antonio.+Dr. [[https://wp.uthscsa.edu/mimg/team-member/ellen-kraig-ph-d/|Ellen Kraig]], an immunologist, and Dr. [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/0V71EU5IM/Kellogg,-Dean-L.-Jr.|Dean Kellogg]], a physiologist, both from the University of Texas Health Science Center at San Antonio. 
  
-Dr. [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/0V71EU5IM/Kellogg,-Dean-L.-Jr.|Dean Kellogg]], a physiologist from the University of Texas Health Science Center at San Antonio.+===== DNA methylation analysis =====
  
 +We follow the Bioconductor [[https://www.bioconductor.org/packages/release/workflows/vignettes/methylationArrayAnalysis/inst/doc/methylationArrayAnalysis.html#differential-methylation-analysis|workflow]] to identify the probes and regions that are differentially methylation due to Rapamycin treatment.