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serum_biomarkers_for_neurodegeneration [2019/12/03 22:56] – created admin | serum_biomarkers_for_neurodegeneration [2019/12/25 01:51] (current) – [Analysis] admin |
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| ====== Serum biomarkers for neurodegeneration ====== |
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===== Objectives ===== | ===== Objectives ===== |
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To investigate whether concentrations of novel serum biomarkers for neurodegeneration individually and collectively have diagnostic accuracy for AD in Hispanic and white non-Hispanic group. | Identify novel serum biomarkers for neurodegeneration that allow accurate diagnosis of Alzheimer's disease (AD) in Hispanic and non-Hispanic white populations (Specific {{:analysis_plan.docx|Aims}} ). |
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| ===== Data ===== |
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| - Six proteins were measured in blood samples of ~1200 Hispanic and ~500 non-Hispanic white participants. Covariates include gender, education, and age. |
| - The cognitive status of participants were assessed in several visits over years. The number of visits and time intervals between visits vary across participants. |
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| ===== Collaborators ===== |
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| Dr. Sudha [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/53266/Seshadri,-Sudha|Seshadri]], the Founding director of the Glenn [[https://biggsinstitute.org/|Biggs]] Institute for Alzheimer's & Neurodegenerative Diseases, and Dr. Mitzi [[https://biggsinstitute.org/team-member/mitzi-m-gonzales-ph-d/|Gonzales]] from the Department of Neurology at University of Texas Health Science Center in San Antonio. This study is supported by Texas Alzheimer's Research and Care Consortium (TARCC). |
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| ===== Analysis ===== |
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| - Linear models. |
| - Regularized regression, e.g., the LASSO and [[https://cran.r-project.org/web/packages/FeaLect/index.html|FeaLect]]. |
| - Hidden Markov Models (HMM). |
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| ===== Related work ===== |
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| - Eagan, Danielle E., et al. "Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults." Cardiovascular psychiatry and neurology 2012 ([[https://www.hindawi.com/journals/cpn/2012/120540/|2012]]). |
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