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serum_biomarkers_for_neurodegeneration [2019/12/03 23:11] – adminserum_biomarkers_for_neurodegeneration [2019/12/25 01:51] (current) – [Analysis] admin
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 +====== Serum biomarkers for neurodegeneration ======
 +
 ===== Objectives ===== ===== Objectives =====
  
-Identify novel serum biomarkers for neurodegeneration that allow accurate diagnosis of Alzheimer's disease (AD) in Hispanic and non-Hispanic white populations.+Identify novel serum biomarkers for neurodegeneration that allow accurate diagnosis of Alzheimer's disease (AD) in Hispanic and non-Hispanic white populations (Specific {{:analysis_plan.docx|Aims}} ). 
 + 
 +===== Data ===== 
 + 
 +  - Six proteins were measured in blood samples of ~1200 Hispanic and ~500 non-Hispanic white participants. Covariates include gender, education, and age. 
 +  - The cognitive status of participants were assessed in several visits over years. The number of visits and time intervals between visits vary across participants. 
 + 
 + 
 +===== Collaborators ===== 
 + 
 +Dr. Sudha [[https://www.uthscsa.edu/academics/biomedical-sciences/faculty/profile/53266/Seshadri,-Sudha|Seshadri]], the Founding director of the Glenn [[https://biggsinstitute.org/|Biggs]] Institute for Alzheimer's & Neurodegenerative Diseases, and Dr. Mitzi [[https://biggsinstitute.org/team-member/mitzi-m-gonzales-ph-d/|Gonzales]] from the Department of Neurology at University of Texas Health Science Center in San Antonio. This study is supported by Texas Alzheimer's Research and Care Consortium (TARCC). 
 + 
 + 
 +===== Analysis ===== 
 + 
 +  - Linear models. 
 +  - Regularized regression, e.g., the LASSO and [[https://cran.r-project.org/web/packages/FeaLect/index.html|FeaLect]]. 
 +  - Hidden Markov Models (HMM). 
 + 
 + 
 +===== Related work ===== 
 + 
 +  - Eagan, Danielle E., et al. "Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults." Cardiovascular psychiatry and neurology 2012 ([[https://www.hindawi.com/journals/cpn/2012/120540/|2012]]).