Identify novel serum biomarkers for neurodegeneration that allow accurate diagnosis of Alzheimer's disease (AD) in Hispanic and non-Hispanic white populations.

1. DNA methylation data of 29 subjects were measured in 2019 using Infinium MethylationEpic V1 Array. PBMC samples were collected before and after Rapamycin (16 subjects) and placebo (13 subjects) treatment for 6-8 weeks.

Dr. Ellen Kraig, an immunologist, and Dr. Dean Kellogg, a physiologist, both from the University of Texas Health Science Center at San Antonio.

We follow the Bioconductor workflow to identify the probes and regions that are differentially methylation due to Rapamycin treatment.

1. Kraig, Ellen, et al. “A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.” Experimental gerontology 105 (2018): 53-69.